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pentobarbital will minimize the extent or influence of abemaciclib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of abemaciclib with robust CYP3A4 inducers minimizes plasma concentration of abemaciclib and its metabolites.Even though it can be used to be a sedative and anticonvulsan